Stem Cell & Regenerative Medicine

Neurodegenerative Disease

Neurodegenerative disease  is caused by a continuous loss of structure or function of neurons, a process known as neurodegeneration.Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's, Huntington's disease, multiple system atrophy, and prion disease. Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of the structure and function of the nervous system. These conditions, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), primarily affect neurons in the brain and spinal cord, leading to gradual loss of cognitive and motor functions. The causes are often linked to genetic mutations, protein misfolding, oxidative stress, or environmental factors. Currently, these diseases are incurable, and treatment options focus on managing symptoms and slowing disease progression. Research continues to explore potential therapies, including gene editing, stem cells, and neuroprotective drugs.Because there is no known way to reverse the ongoing neurological decline, these diseases are considered incurable; however studies have shown that two major factors contribute to the formation of neurodegeneration by oxidative stress and inflammation. Biomedical studies have revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (such as proteinopathy) and cell death caused by death.