Stem Cell & Regenerative Medicine

Exosomes, Extracellular Vesicles & Cell-Free Therapeutics

Exosomes and extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication, playing a central role in tissue repair and regeneration. These nanoscale vesicles, secreted by stem cells and other cell types, carry proteins, lipids, and nucleic acids that can modulate immune responses, stimulate angiogenesis, and promote cellular proliferation. Cell-free therapies leveraging exosomes provide a promising alternative to direct stem cell transplantation, reducing risks of tumorigenicity, immune rejection, and ethical concerns. Advances in isolation techniques, cargo engineering, and targeted delivery systems have enhanced the therapeutic potential of exosomes for cardiovascular, neurological, and musculoskeletal disorders. Clinical studies demonstrate their efficacy in wound healing, cardiac repair, and neuroprotection. This session explores bioengineering strategies to load exosomes with regenerative molecules, improve biodistribution, and integrate with biomaterials for controlled release. Attendees will gain insight into the mechanisms, clinical applications, and regulatory challenges of EV-based therapies, positioning them as a transformative tool in next-generation regenerative medicine.